Genetic Associations of IL-2 (rs2069762) and EGR3 (rs3750192) Polymorphisms with Schizophrenia: A Meta-Analysis
Genetic Associations of IL-2 (rs2069762) and EGR3 (rs3750192) Polymorphisms with Schizophrenia: A Meta-Analysis
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Highlights: 1.The novelty of this study lies in its thorough examination of gene Towels polymorphisms and their associations with schizophrenia risk across different populations.2.This meta-analysis provides new insights by highlighting the lack of reliable association for interleukin-2 (IL-2) rs2069762 and revealing a substantial protective effect of early growth response 3 (EGR3) rs3750192 in specific ethnic groups, particularly among Polish and Chinese.
Abstract Although genome-wide association studies have identified numerous genes linked to schizophrenia, their specific roles remain unclear.This meta-analysis sought to explore the association of polymorphisms in the interleukin-2 (IL-2) rs2069762 and early growth response 3 (EGR3) rs3750192 with schizophrenia susceptibility.The literature review on schizophrenia was conducted using databases, such as PubMed, Embase, and Google Scholar, with specific search terms.The inclusion criteria focused on studies linking IL-2, EGR3, and schizophrenia, requiring genotypic and allele frequency data.
The data extraction included genotypic and allelic frequencies, Wire Strippers sample size, publication details, Hardy-Weinberg equilibrium values, and ethnicities.Fixed-effect and random-effect models were employed for analyses under allele, dominant, recessive, and overdominant models.Subgroup analyses were conducted by ethnicity.No significant associations with schizophrenia risk were found for IL-2 rs2069762 across all genetic models.
The allele (OR=0.94, p=0.34), dominant (OR=0.85, p=0.
55), recessive (OR=0.93, p=0.76), and overdominant (OR=0.94, p=0.
76) models showed non-significant results.Conversely, EGR3 rs3750192 demonstrated a significant association in the dominant (OR=0.73, p=0.012) and homozygous (OR=0.
70, p=0.004) models, suggesting a protective effect.The subgroup analyses indicated ethnic differences, with Polish and Chinese showing significant protective effects for IL-2 and EGR3, respectively.While IL-2 rs2069762 lacks a consistent association with schizophrenia, EGR3 rs3750192 may confer a protective effect, particularly in certain ethnic groups.